Gastroretentive Drug Delivery System - A Novel Approach
R.N Patil Raju Nivrutti Patil
Shivnagar Vidya Prasarak Mandal's College Of Pharmacy, Malegaon BkII,
Tal Baramati , Dist-Pune (Maharashtra) India
Abstract:
Several approaches are currently used to retain the dosage form in the stomach. These include bioadhesive systems, swelling and expanding systems, floating systems, and other delayed gastric emptying devices. The principle of preparation offers a simple and practical approach to achieve increased gastric time for the dosage form and sustained drug release.
The major objective of the present investigation was to develop a gastro retentive drug delivery system containing Diclofenac sodium and to evaluate floating tablet. Diclofenac sodium is used as antipyretic and analgesic. The popularity of this drug is related to several beneficial properties. Diclofenac sodium is poorly soluble in water with erratic oral absorption and bioavailability less than 70% preparing the drug in a floating dosage form can control the extent of bioavailability for such a poorly water soluble drug.
Various batches of Diclofenac sodium floating tablets were prepared and evaluated for evaluation parameters like organoleptic properties, size and shape, weight variation, hardness, friability, disintegration test and floating test. Result indicated that tablet formulation containing high level of HPMC and low level of ethyl cellulose shows low in-vitro floating time. Other evaluation parameters of all batches were found to be acceptable.
